Abstract: Nutritional imbalance has become a significant public health issue, necessitating more targeted measures. As an effective approach to improving nutritional balance and maintaining health, personalized nutrition plans tailored to individual needs have garnered widespread attention. With the rapid development in the fields of genomics and nutrigenetics, research indicates that the accumulation of genetic variations can alter the effects of nutritional supplements, highlighting their indispensable role in genotype-based personalized nutrition. Furthermore, through relevant genetic variations, the metabolism of nutrients such as lipids (especially ω-3 polyunsaturated fatty acids), glucose, vitamin A, folate, vitamin D, iron, and calcium can be effectively improved. This review focuses on summarizing the associations between key genetic variations and specific nutrients found in existing literature, as well as how these variations influence the effects of specific nutritional supplements. Although further research in this direction is still needed, such evidence provides valuable insights for utilizing genetic information to guide appropriate interventions, thereby paving the way for a smooth transition from traditional one-size-fits-all approaches to genotype-based personalized nutrition.

Personalized Nutrition: A Review of Genotype-Based Nutritional Supplementation.pdf